A transcriptomic analysis of the EK1. Br strain of human fibroblastoid keratocytes: the effects of growth, quiescence and senescence
D Kipling, DL Jones, SK Smith, PJ Giles… - Experimental eye …, 2009 - Elsevier
There is a growing need within ocular research for well-defined cellular models of normal
corneal biology. To meet this need we created and partially characterised a standard strain
of human fibroblastoid keratocytes (EK1. Br) and demonstrated that phenotypic changes
occur within these cells with replicative senescence in vitro. Using Affymetrix HG-U133A
oligonucleotide arrays, this paper reports both a comprehensive analysis of the
transcriptome of EK1. Br in the growing, quiescent and senescent states and a comparison …
corneal biology. To meet this need we created and partially characterised a standard strain
of human fibroblastoid keratocytes (EK1. Br) and demonstrated that phenotypic changes
occur within these cells with replicative senescence in vitro. Using Affymetrix HG-U133A
oligonucleotide arrays, this paper reports both a comprehensive analysis of the
transcriptome of EK1. Br in the growing, quiescent and senescent states and a comparison …