Age-related defects in the cytoskeleton signaling pathways of CD4 T cells

GG Garcia, RA Miller - Ageing research reviews, 2011 - Elsevier
GG Garcia, RA Miller
Ageing research reviews, 2011Elsevier
It has been postulated that the cytoskeleton controls many aspects of T cell function,
including activation, proliferation and apoptosis. Recent advances in our understanding of F-
actin polymerization and the Ezrin-Radixin-Moesin (ERM) family of cytoskeleton signal
proteins have provided new insights into immunological synapse formation during T cell
activation. During aging there is a significant decline of T cell function largely attributable to
declines in activation of CD4 T cells and defects in the formation of the immunological …
It has been postulated that the cytoskeleton controls many aspects of T cell function, including activation, proliferation and apoptosis. Recent advances in our understanding of F-actin polymerization and the Ezrin-Radixin-Moesin (ERM) family of cytoskeleton signal proteins have provided new insights into immunological synapse formation during T cell activation. During aging there is a significant decline of T cell function largely attributable to declines in activation of CD4 T cells and defects in the formation of the immunological synapse. Here we discuss recent progress in the understanding of how aging alters F-actin and ERM proteins in mouse CD4 T cells, and the implications of these changes for the T cell activation process.
Elsevier