Regulation of longevity and stress resistance by Sch9 in yeast
P Fabrizio, F Pozza, SD Pletcher, CM Gendron… - Science, 2001 - science.org
P Fabrizio, F Pozza, SD Pletcher, CM Gendron, VD Longo
Science, 2001•science.orgThe protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals
and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis
elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces
cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to
Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-
resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this …
and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis
elegans. We screened for long-lived mutants in nondividing yeast Saccharomyces
cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to
Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-
resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this …
The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividing yeastSaccharomyces cerevisiae and identified mutations in adenylate cyclase and SCH9, which is homologous to Akt/PKB, that increase resistance to oxidants and extend life-span by up to threefold. Stress-resistance transcription factors Msn2/Msn4 and protein kinase Rim15 were required for this life-span extension. These results indicate that longevity is associated with increased investment in maintenance and show that highly conserved genes play similar roles in life-span regulation in S. cerevisiae and higher eukaryotes.
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