A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila
A Duttaroy, A Paul, M Kundu, A Belton - Genetics, 2003 - academic.oup.com
A Duttaroy, A Paul, M Kundu, A Belton
Genetics, 2003•academic.oup.comA null mutation for the Sod2 gene, Sod2 n283, was obtained in Drosophila melanogaster.
Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following
eclosion, a phenotype reminiscent of mice, where Sod2–/–progeny suffer neonatal lethality.
Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.
Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following
eclosion, a phenotype reminiscent of mice, where Sod2–/–progeny suffer neonatal lethality.
Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.
Abstract
A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2–/– progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.
Oxford University Press