Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration
J Müller-Höcker - Journal of the neurological sciences, 1990 - Elsevier
Cytochromec oxidase (complex IV of the respiratory chain) was studied histochemically in
human limb muscle (n= 109) and diaphragm (n= 115) obtained at autopsy revealing
randomly distributed muscle fibres without enzyme activity. The defects were present both in
normal type I and type II fibres and in ragged red like fibres with increased content of
mitochondria. In both organs an age associated manifestation of the defect was observed.
First defects occurred sporadically in the 3rd and 4th decade, but were present from the 6th …
human limb muscle (n= 109) and diaphragm (n= 115) obtained at autopsy revealing
randomly distributed muscle fibres without enzyme activity. The defects were present both in
normal type I and type II fibres and in ragged red like fibres with increased content of
mitochondria. In both organs an age associated manifestation of the defect was observed.
First defects occurred sporadically in the 3rd and 4th decade, but were present from the 6th …