Active autophagy coupled with rapid mitochondrial fusion and fission constitutes an
important mitochondrial quality control mechanism and is critical to cellular health. In our
previous studies, we found that exposure of cells to nicotinamide causes a decrease in
mitochondrial content and an increase in mitochondrial membrane potential (MMP) by
activating autophagy and inducing mitochondrial fragmentation. Here, we present evidence
to show that the effect of nicotinamide is mediated through an increase of the [NAD+]/[NADH] …