Organism aging is a process of time and maturation culminating in senescence and death.
The molecular details that define and determine aging have been intensely investigated. It
has become appreciated that the process is partly an accumulation of random yet inevitable
changes, but it can be strongly affected by genes that alter lifespan. In this review, we
consider how NAD+ metabolism plays important roles in the random patterns of aging, and
also in the more programmatic aspects. The derivatives of NAD+, such as reduced and …