[HTML][HTML] Plasma phospholipid transfer activity is essential for increased atherogenesis in PLTP transgenic mice: a mutation-inactivation study
H Samyn, M Moerland, T van Gent, R van Haperen… - Journal of lipid …, 2008 - ASBMB
Plasma phospholipid transfer protein (PLTP) interacts with HDL particles and facilitates the
transfer of phospholipids from triglyceride (TG)-rich lipoproteins to HDL. Overexpressing
human PLTP in mice increases the susceptibility to atherosclerosis. In human plasma, high-
active and low-active forms of PLTP exist. To elucidate the contribution of phospholipid
transfer activity to changes in lipoprotein metabolism and atherogenesis, we developed
mice expressing mutant PLTP, still able to associate with HDL but lacking phospholipid …
transfer of phospholipids from triglyceride (TG)-rich lipoproteins to HDL. Overexpressing
human PLTP in mice increases the susceptibility to atherosclerosis. In human plasma, high-
active and low-active forms of PLTP exist. To elucidate the contribution of phospholipid
transfer activity to changes in lipoprotein metabolism and atherogenesis, we developed
mice expressing mutant PLTP, still able to associate with HDL but lacking phospholipid …