Cytokines and organ failure in acute pancreatitis: inflammatory response in acute pancreatitis
ML Malmstrøm, MB Hansen, AM Andersen, AK Ersbøll… - Pancreas, 2012 - journals.lww.com
Pancreas, 2012•journals.lww.com
Objectives We aimed at synchronously examining the early time course of 4 proinflammatory
cytokines as predictive factors for development of organ failure in patients with acute
pancreatitis (AP). Methods Interleukin (IL) 6, IL-8, IL-18, and tumor necrosis factor α were
measured on admission and at days 1, 2, and 14 in 60 patients admitted with first attack of
AP. The prediction of single-organ and multiorgan failure from the cytokine profiles was
evaluated by receiver operating characteristic analyses. Results Interleukin 6 and IL-8 levels …
cytokines as predictive factors for development of organ failure in patients with acute
pancreatitis (AP). Methods Interleukin (IL) 6, IL-8, IL-18, and tumor necrosis factor α were
measured on admission and at days 1, 2, and 14 in 60 patients admitted with first attack of
AP. The prediction of single-organ and multiorgan failure from the cytokine profiles was
evaluated by receiver operating characteristic analyses. Results Interleukin 6 and IL-8 levels …
Abstract
Objectives
We aimed at synchronously examining the early time course of 4 proinflammatory cytokines as predictive factors for development of organ failure in patients with acute pancreatitis (AP).
Methods
Interleukin (IL) 6, IL-8, IL-18, and tumor necrosis factor α were measured on admission and at days 1, 2, and 14 in 60 patients admitted with first attack of AP. The prediction of single-organ and multiorgan failure from the cytokine profiles was evaluated by receiver operating characteristic analyses.
Results
Interleukin 6 and IL-8 levels were significantly higher in patients who developed renal, respiratory, and circulatory failure, as was the case for patients with multiorgan failure. Interleukin 18 levels were significantly elevated in renal and respiratory failure only. Tumor necrosis factor α was significantly elevated in all types of organ failures, except for intestinal failure.
Conclusions
Synchronous measurements of 4 cytokines demonstrated IL-6 and IL-8 to be predictive as early surrogate markers with regard to organ failures in AP. The fact that all of the cytokines were particularly elevated in patients with organ failures calls for evaluation of agents modifying the severe inflammatory response in patients with AP.
Lippincott Williams & Wilkins