T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC
D Haasch, YW Chen, RM Reilly, XG Chiou… - Cellular …, 2002 - Elsevier
In a search for novel early T cell activation transcripts, we identified expressed sequence
tags (ESTs) more abundantly expressed in normal human CD4+ T lymphocytes fully
activated by a 5h exposure to CD3 plus CD28 mAbs, compared to the same cells stimulated
with either CD3 mAb or CD28 mAb alone. An EST was identified that hybridized with a 1.7
kb transcript expressed in activated T cells but was undetectable by Northern blot analysis in
resting T cells or other normal tissues. The T cell transcript was maximally induced within 6h …
tags (ESTs) more abundantly expressed in normal human CD4+ T lymphocytes fully
activated by a 5h exposure to CD3 plus CD28 mAbs, compared to the same cells stimulated
with either CD3 mAb or CD28 mAb alone. An EST was identified that hybridized with a 1.7
kb transcript expressed in activated T cells but was undetectable by Northern blot analysis in
resting T cells or other normal tissues. The T cell transcript was maximally induced within 6h …