A monoclonal antibody that inhibits mouse tissue factor function
D Kirchhofer, P Moran, S Bullens, F Peale… - Journal of Thrombosis …, 2005 - jthjournal.org
The tissue factor (TF)/factor VIIa (FVIIa) complex not only controls hemostatic processes, but
also contributes to thrombosis-related diseases and cancer. Genetic mouse models of
human diseases (eg prostate-and colorectal cancer, sickle cell anemia) could serve to
investigate further the role of TF/FVIIa in disease progression. However, such attempts are
hampered by the lack of specific antimouse TF reagents. Here, we describe the generation
of the monoclonal rat antimouse TF antibody 1H1. The antibody was produced by …
also contributes to thrombosis-related diseases and cancer. Genetic mouse models of
human diseases (eg prostate-and colorectal cancer, sickle cell anemia) could serve to
investigate further the role of TF/FVIIa in disease progression. However, such attempts are
hampered by the lack of specific antimouse TF reagents. Here, we describe the generation
of the monoclonal rat antimouse TF antibody 1H1. The antibody was produced by …