Interferons: signaling, antiviral and viral evasion
CA Bonjardim, PCP Ferreira, EG Kroon - Immunology letters, 2009 - Elsevier
Interferons (IFNs) were discovered as antiviral agents 50 years ago, and enormous progress
has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as
the cytokines that bridge the innate and adaptive immunity soon after the recognition of
pathogen-associated molecular patterns (PAMPs) by the infected host. Notably, a unifying
mechanism for type I IFN production has been established upon innate immune detection.
Thus, TLR 3, 4, 7 and 9 associate endosomal recognition of PAMPs to type I IFN responses …
has been made since then. Nowadays, IFNs (specifically type I IFNs), have been ascribed as
the cytokines that bridge the innate and adaptive immunity soon after the recognition of
pathogen-associated molecular patterns (PAMPs) by the infected host. Notably, a unifying
mechanism for type I IFN production has been established upon innate immune detection.
Thus, TLR 3, 4, 7 and 9 associate endosomal recognition of PAMPs to type I IFN responses …