Novel antagonist antibody to TLR3 blocks poly (I: C)-induced inflammation in vivo and in vitro
RA Bunting, KE Duffy, RJ Lamb, LR San Mateo… - Cellular …, 2011 - Elsevier
Toll-like receptor 3 (TLR3) binds and signals in response to dsRNA and poly (I: C), a
synthetic double stranded RNA analog. Activation of TLR3 triggers innate responses that
may play a protective or detrimental role in viral infections or in immune-mediated
inflammatory diseases through amplification of inflammation. Two monoclonal antibodies,
CNTO4685 (rat anti-mouse TLR3) and CNTO5429 (CDRs from CNTO4685 grafted onto a
mouse IgG1 scaffold) were generated and characterized. These mAbs bind the extracellular …
synthetic double stranded RNA analog. Activation of TLR3 triggers innate responses that
may play a protective or detrimental role in viral infections or in immune-mediated
inflammatory diseases through amplification of inflammation. Two monoclonal antibodies,
CNTO4685 (rat anti-mouse TLR3) and CNTO5429 (CDRs from CNTO4685 grafted onto a
mouse IgG1 scaffold) were generated and characterized. These mAbs bind the extracellular …