Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma

C Karagiannidis, M Akdis, P Holopainen… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: T regulatory (Treg) cells are characterized by expression of suppressive
cytokines and the transcription factor FOXP3. They play a key role in balancing immune
responses and maintain peripheral tolerance against antigens and allergens. The loss of
peripheral tolerance against allergens causes diseases that can be therapeutically
controlled with glucocorticoids. OBJECTIVE: The present study investigates whether
glucocorticoids affect the activity of Treg cells on the basis of FOXP3 and cytokine …