Hypercholesterolaemia and circulating levels of CXC chemokines in apoE* 3 Leiden mice
N Murphy, DC Grimsditch, S Parkin, MP Vidgeon-Hart… - Atherosclerosis, 2002 - Elsevier
Hyperlipidaemia may accelerate the development of atherosclerosis by enhancing the
expression of chemokines by cells within the arterial wall. Chemokines of the CC subfamily
are clearly implicated in atherogenesis; however, recent reports suggest that CXC
chemokines may play a hitherto unrecognised role in monocyte recruitment into
atheromatous lesions expressing these molecules. Here, we examine whether circulating
levels of CXC chemokines may reflect the pathogenic changes occurring during early …
expression of chemokines by cells within the arterial wall. Chemokines of the CC subfamily
are clearly implicated in atherogenesis; however, recent reports suggest that CXC
chemokines may play a hitherto unrecognised role in monocyte recruitment into
atheromatous lesions expressing these molecules. Here, we examine whether circulating
levels of CXC chemokines may reflect the pathogenic changes occurring during early …