Genetic variation in myelin oligodendrocyte glycoprotein expression and susceptibility to experimental autoimmune encephalomyelitis
M Pagany, M Jagodic, C Bourquin, T Olsson… - Journal of …, 2003 - Elsevier
Myelin oligodendrocyte glycoprotein (MOG) is encoded within the RT1. M region of the rat
MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis
(EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG–EAE is
associated with higher expression of MOG mRNA and protein in the nervous system than in
the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune
system, but there was no correlation with disease susceptibility. These results suggest that …
MHC a susceptibility locus for MOG-induced experimental autoimmune encephalomyelitis
(EAE). We report that the enhanced susceptibility of Brown Norway (BN) rats to MOG–EAE is
associated with higher expression of MOG mRNA and protein in the nervous system than in
the less susceptible Lewis (LEW) strain. MOG mRNA was also detected in the immune
system, but there was no correlation with disease susceptibility. These results suggest that …