Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial

R Thadhani, E Appelbaum, Y Pritchett, Y Chang… - Jama, 2012 - jamanetwork.com
Context Vitamin D is associated with decreased cardiovascular-related morbidity and
mortality, possibly by modifying cardiac structure and function, yet firm evidence for either
remains lacking. Objective To determine the effects of an active vitamin D compound,
paricalcitol, on left ventricular mass over 48 weeks in patients with an estimated glomerular
filtration rate of 15 to 60 mL/min/1.73 m 2. Design, Setting, and Participants Multinational,
double-blind, randomized placebo-controlled trial among 227 patients with chronic kidney …