mTOR signaling in disease
E Dazert, MN Hall - Current opinion in cell biology, 2011 - Elsevier
E Dazert, MN Hall
Current opinion in cell biology, 2011•ElsevierThe target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in
response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has
been implicated in major disease. Here we review recent findings on the role of mTOR in
cancer, metabolic disorders, neurological diseases, and inflammation.
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in
response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has
been implicated in major disease. Here we review recent findings on the role of mTOR in
cancer, metabolic disorders, neurological diseases, and inflammation.
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
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