A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells
M Guo, S Gong, S Maric, Z Misulovin, M Pack… - Human immunology, 2000 - Elsevier
DEC-205 is a multilectin receptor for adsorptive endocytosis, expressed in mouse dendritic
cells (DC) and some epithelia. DEC-205 is homologous to the macrophage mannose
receptor (MMR). A cDNA for murine DEC-205 was used to identify 3 overlapping human
DEC-205 clones from a lymphocyte library. The human homologue is a transmembrane
protein of 1722 aminoacids with 10 externally disposed C-type lectin domains having 77%
identity to the mouse counterpart. The NH2 terminal cysteine-rich and fibronectin type II …
cells (DC) and some epithelia. DEC-205 is homologous to the macrophage mannose
receptor (MMR). A cDNA for murine DEC-205 was used to identify 3 overlapping human
DEC-205 clones from a lymphocyte library. The human homologue is a transmembrane
protein of 1722 aminoacids with 10 externally disposed C-type lectin domains having 77%
identity to the mouse counterpart. The NH2 terminal cysteine-rich and fibronectin type II …