Sphingosine-1-phosphate: an enigmatic signalling lipid

S Spiegel, S Milstien - Nature reviews Molecular cell biology, 2003 - nature.com
S Spiegel, S Milstien
Nature reviews Molecular cell biology, 2003nature.com
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions.
In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors.
These S1P receptors are differentially expressed, coupled to various G proteins, and
regulate angiogenesis, vascular maturation, cardiac development and immunity, and are
important for directed cell movement.
Abstract
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.
nature.com