Ceramide in apoptosis: an overview and current perspectives
BJ Pettus, CE Chalfant, YA Hannun - … (BBA)-Molecular and Cell Biology of …, 2002 - Elsevier
BJ Pettus, CE Chalfant, YA Hannun
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2002•ElsevierRecent years have witnessed significant advances in the understanding of the role of
ceramide in apoptosis. This review summarizes these recent findings and discusses insights
from studies of ceramide metabolism, topology, and effector actions. The recent identification
of several genes for enzymes of ceramide metabolism, the development of mass
spectrometric methods for ceramide analysis, and the increasing molecular and
pharmacological tools to probe ceramide metabolism and function promise an accelerated …
ceramide in apoptosis. This review summarizes these recent findings and discusses insights
from studies of ceramide metabolism, topology, and effector actions. The recent identification
of several genes for enzymes of ceramide metabolism, the development of mass
spectrometric methods for ceramide analysis, and the increasing molecular and
pharmacological tools to probe ceramide metabolism and function promise an accelerated …
Recent years have witnessed significant advances in the understanding of the role of ceramide in apoptosis. This review summarizes these recent findings and discusses insights from studies of ceramide metabolism, topology, and effector actions. The recent identification of several genes for enzymes of ceramide metabolism, the development of mass spectrometric methods for ceramide analysis, and the increasing molecular and pharmacological tools to probe ceramide metabolism and function promise an accelerated phase in defining the molecular and biochemical details of the role of ceramide in apoptosis.
Elsevier