The alliance of sphingosine-1-phosphate and its receptors in immunity

J Rivera, RL Proia, A Olivera - Nature Reviews Immunology, 2008 - nature.com
J Rivera, RL Proia, A Olivera
Nature Reviews Immunology, 2008nature.com
Abstract Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-
membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is
increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the
immune function of S1P results from the engagement of a family of G-protein-coupled
receptors (S1PR1–S1PR5). Recent findings on the role of S1P in immunosurveillance, the
discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new …
Abstract
Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1–S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.
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