Arterial calcification is very common in patients with chronic kidney disease (CKD) and other
chronic inflammatory disorders such as diabetes mellitus. Arterial calcification is associated
with significant morbidity and increased early mortality. Vascular calcification is a highly
orchestrated process that entrains a repertoire of transcription factors and involves the
activation of an osteogenic program that recapitulates the molecular fingerprints seen in
bone formation. Recent studies have implicated the inflammatory cytokine tumor necrosis …