Improved method for accurate and efficient quantification of MRS data with use of prior knowledge

L Vanhamme, A van den Boogaart… - Journal of magnetic …, 1997 - Elsevier
We introduce AMARES (advancedmethod foraccurate, robust, andefficientspectral fitting), an
improved method for accurately and efficiently estimating the parameters of noisy magnetic
resonance spectroscopy (MRS) signals in the time domain. As a reference time domain
method we take VARPRO. VARPRO uses a simple Levenberg–Marquardt algorithm to
minimize the variable projection functional. This variable projection functional is derived
from a general functional, which minimizes the sum of squared differences between the data …