The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4
J Turner, AA Frank, JV Brooks… - Experimental …, 2001 - Elsevier
The aging process is associated with alterations in the immune system. Some of the
changes reported are an increase in the proportion of B lymphocytes, and a shift to a TH2-
like cytokine environment. It has been hypothesized that the development of
immunopathology within the lung during tuberculosis is linked to increased interleukin-4 (IL-
4) production. In addition, a role for B cells in maintaining granuloma integrity has been
recently proposed. This study investigated the role of B cells and IL-4 during the long-term …
changes reported are an increase in the proportion of B lymphocytes, and a shift to a TH2-
like cytokine environment. It has been hypothesized that the development of
immunopathology within the lung during tuberculosis is linked to increased interleukin-4 (IL-
4) production. In addition, a role for B cells in maintaining granuloma integrity has been
recently proposed. This study investigated the role of B cells and IL-4 during the long-term …