Breast cancer patients have an extremely high rate of bone metastases. Morphological
analyses of the bones in most of the patients have revealed the mixed bone lesions,
comprising both osteolytic and osteoblastic elements. β-Catenin plays a key role in both
embryonic skeletogenesis and postnatal bone regeneration. Although this pathway is also
involved in many bone malignancy, such as osteosarcoma and prostate cancer-induced
bone metastases, its regulation of breast cancer bone metastases remains unknown. Here …