Visualization of vascular Ca2+ signaling triggered by paracrine derived ROS
K Mallilankaraman, RK Gandhirajan… - JoVE (Journal of …, 2011 - jove.com
Oxidative stress has been implicated in a number of pathologic conditions including
ischemia/reperfusion damage and sepsis. The concept of oxidative stress refers to the
aberrant formation of ROS (reactive oxygen species), which include O2•-, H2O2, and
hydroxyl radicals. Reactive oxygen species influences a multitude of cellular processes
including signal transduction, cell proliferation and cell death1-6. ROS have the potential to
damage vascular and organ cells directly, and can initiate secondary chemical reactions …
ischemia/reperfusion damage and sepsis. The concept of oxidative stress refers to the
aberrant formation of ROS (reactive oxygen species), which include O2•-, H2O2, and
hydroxyl radicals. Reactive oxygen species influences a multitude of cellular processes
including signal transduction, cell proliferation and cell death1-6. ROS have the potential to
damage vascular and organ cells directly, and can initiate secondary chemical reactions …