There is increasing evidence that intracellular reactive oxygen species (ROS) play a role in
cell signaling and that the NADPH oxidase is a major source of ROS in endothelial cells. At
low concentrations, agonist stimulation of membrane receptors generates intracellular ROS
and repetitive oscillations of intracellular Ca 2+ concentration ([Ca 2+] i) in human
endothelial cells. The present study was performed to examine whether ROS are important
in the generation or maintenance of [Ca 2+] i oscillations in human aortic endothelial cells …