[HTML][HTML] Chromosome 11q13. 5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations

GM O'Regan, LE Campbell, HJ Cordell… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: Atopic eczema is a common inflammatory skin disease with multifactorial
etiology. The genetic basis is incompletely understood; however, loss of function mutations
in the filaggrin gene (FLG) are the most significant and widely replicated genetic risk factor
reported to date. The first genome-wide association study in atopic eczema recently
identified 2 novel genetic variants in association with eczema susceptibility: a single
nucleotide polymorphism on chromosome 11q13. 5 (rs7927894) and a single nucleotide …