[HTML][HTML] CLEC‐2 is not required for platelet aggregation at arteriolar shear
CE Hughes, L NAVARRO‐NÚÑEZ… - Journal of Thrombosis …, 2010 - jthjournal.org
The C-type lectin receptor CLEC-2 is expressed primarily on the surface of platelets, where it
is present as a dimer, and is found at low level on a subpopulation of other hematopoietic
cells, including mouse neutrophils [1–4] Clustering of CLEC-2 by the snake venom toxin
rhodocytin, specific antibodies or its endogenous ligand, podoplanin, elicits powerful
activation of platelets through a pathway that is similar to that used by the collagen receptor
glycoprotein VI (GPVI)[4–6]. The cytosolic tail of CLEC-2 contains a conserved YxxL …
is present as a dimer, and is found at low level on a subpopulation of other hematopoietic
cells, including mouse neutrophils [1–4] Clustering of CLEC-2 by the snake venom toxin
rhodocytin, specific antibodies or its endogenous ligand, podoplanin, elicits powerful
activation of platelets through a pathway that is similar to that used by the collagen receptor
glycoprotein VI (GPVI)[4–6]. The cytosolic tail of CLEC-2 contains a conserved YxxL …