[HTML][HTML] Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor
D Umeda, S Yano, K Yamada, H Tachibana - Journal of Biological …, 2008 - ASBMB
(–)-Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, has been
shown to be a potent chemopreventive agent. Recently, 67-kDa laminin receptor (67LR) has
been identified as a cell surface receptor for EGCG that mediates the anticancer activity of
EGCG. Indeed, expression of 67LR confers EGCG responsiveness to tumor cells; however,
the molecular basis for the anticancer activity of EGCG in vivo is not entirely understood.
Here we show that (i) using a direct genetic screen, eukaryotic translation elongation factor …
shown to be a potent chemopreventive agent. Recently, 67-kDa laminin receptor (67LR) has
been identified as a cell surface receptor for EGCG that mediates the anticancer activity of
EGCG. Indeed, expression of 67LR confers EGCG responsiveness to tumor cells; however,
the molecular basis for the anticancer activity of EGCG in vivo is not entirely understood.
Here we show that (i) using a direct genetic screen, eukaryotic translation elongation factor …