[HTML][HTML] Diverse antiapoptotic signaling pathways activated by vasoactive intestinal polypeptide, epidermal growth factor, and phosphatidylinositol 3-kinase in prostate …
KSR Sastry, AJ Smith, Y Karpova, SR Datta… - Journal of biological …, 2006 - ASBMB
It has been demonstrated that vasoactive intestinal polypeptide, epidermal growth factor,
and chronic activation of phosphatidylinositol 3-kinase can protect prostate cancer cells from
apoptosis; however, the signaling pathways that they use and molecules that they target are
unknown. We report that vasoactive intestinal polypeptide, epidermal growth factor, and
phosphatidylinositol 3-kinase activate independent signaling pathways that phosphorylate
the proapoptotic protein BAD. Vasoactive intestinal polypeptide operated via protein kinase …
and chronic activation of phosphatidylinositol 3-kinase can protect prostate cancer cells from
apoptosis; however, the signaling pathways that they use and molecules that they target are
unknown. We report that vasoactive intestinal polypeptide, epidermal growth factor, and
phosphatidylinositol 3-kinase activate independent signaling pathways that phosphorylate
the proapoptotic protein BAD. Vasoactive intestinal polypeptide operated via protein kinase …