[PDF][PDF] Integrative genomic profiling of human prostate cancer

BS Taylor, N Schultz, H Hieronymus, A Gopalan… - Cancer cell, 2010 - cell.com
BS Taylor, N Schultz, H Hieronymus, A Gopalan, Y Xiao, BS Carver, VK Arora, P Kaushik
Cancer cell, 2010cell.com
Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number,
mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified
the nuclear receptor coactivator NCOA2 as an oncogene in∼ 11% of tumors. Additionally,
the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized,
prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as …
Summary
Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in ∼11% of tumors. Additionally, the androgen-driven TMPRSS2-ERG fusion was associated with a previously unrecognized, prostate-specific deletion at chromosome 3p14 that implicates FOXP1, RYBP, and SHQ1 as potential cooperative tumor suppressors. DNA copy-number data from primary tumors revealed that copy-number alterations robustly define clusters of low- and high-risk disease beyond that achieved by Gleason score. The genomic and clinical outcome data from these patients are now made available as a public resource.
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