Brain insulin has widespread metabolic, neurotrophic, and neuromodulatory functions and is
involved in the central regulation of food intake and body weight, learning and memory,
neuronal development, neuronal apoptosis, and aging. To understand the neuromodulatory
role of insulin, we aimed to characterize its yet undefined in vivo electrophysiological effects.
We elected to record from the cerebellar cortex because as this region has average insulin
concentration and insulin receptor content in relation to the whole brain, and has been …