[HTML][HTML] Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-β oligomers
S Jürgensen, LL Antonio, GEA Mussi… - Journal of biological …, 2011 - ASBMB
Soluble oligomers of the amyloid-β peptide (AβOs) accumulate in the brains of Alzheimer
disease (AD) patients and are implicated in synapse failure and early memory loss in AD.
AβOs have been shown to impact synapse function by inhibiting long term potentiation,
facilitating the induction of long term depression and inducing internalization of both AMPA
and NMDA glutamate receptors, critical players in plasticity mechanisms. Because activation
of dopamine D1/D5 receptors plays important roles in memory circuits by increasing the …
disease (AD) patients and are implicated in synapse failure and early memory loss in AD.
AβOs have been shown to impact synapse function by inhibiting long term potentiation,
facilitating the induction of long term depression and inducing internalization of both AMPA
and NMDA glutamate receptors, critical players in plasticity mechanisms. Because activation
of dopamine D1/D5 receptors plays important roles in memory circuits by increasing the …