Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
GG Glenner, CW Wong - Biochemical and biophysical research …, 1984 - Elsevier
GG Glenner, CW Wong
Biochemical and biophysical research communications, 1984•ElsevierA purified protein derived from the twisted β-pleated sheet fibrils in cerebrovascular
amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100
column chromatography with 5 M guanidine-HCl in 1 N acetic acid and by high performance
liquid chromatography. Amino acid sequence analysis and a computer search reveals this
protein to have no homology with any protein sequenced thus far. This protein may be
derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's …
amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100
column chromatography with 5 M guanidine-HCl in 1 N acetic acid and by high performance
liquid chromatography. Amino acid sequence analysis and a computer search reveals this
protein to have no homology with any protein sequenced thus far. This protein may be
derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's …
Summary
A purified protein derived from the twisted β-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HCl in 1 N acetic acid and by high performance liquid chromatography. Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far. This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis.
Elsevier