Alzheimer disease: Insulin resistance and AD--extending the translational path

S Craft - Nature Reviews. Neurology, 2012 - search.proquest.com
S Craft
Nature Reviews. Neurology, 2012search.proquest.com
Two recent studies have carefully characterized amyloid-related brain insulin resistance in
animal models of, and patients with, Alzheimer disease (AD). The researchers show that
exendin-4, a glucagon-like peptide 1 receptor agonist, ameliorates pathology and symptoms
in a mouse model of AD, suggesting a novel therapeutic approach to this disease.
Two recent studies have carefully characterized amyloid-related brain insulin resistance in animal models of, and patients with, Alzheimer disease (AD). The researchers show that exendin-4, a glucagon-like peptide 1 receptor agonist, ameliorates pathology and symptoms in a mouse model of AD, suggesting a novel therapeutic approach to this disease.
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