[HTML][HTML] Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway
M Townsend, T Mehta, DJ Selkoe - Journal of Biological Chemistry, 2007 - ASBMB
Numerous studies have now shown that the amyloid β-protein (Aβ), the principal component
of cerebral plaques in Alzheimer disease, rapidly and potently inhibits certain forms of
synaptic plasticity. The amyloid (or Aβ) hypothesis proposes that the continuous disruption of
normal synaptic physiology by Aβ contributes to the development of Alzheimer disease.
However, there is little consensus about how Aβ mediates this inhibition at the molecular
level. Using mouse primary hippocampal neurons, we observed that a brief treatment with …
of cerebral plaques in Alzheimer disease, rapidly and potently inhibits certain forms of
synaptic plasticity. The amyloid (or Aβ) hypothesis proposes that the continuous disruption of
normal synaptic physiology by Aβ contributes to the development of Alzheimer disease.
However, there is little consensus about how Aβ mediates this inhibition at the molecular
level. Using mouse primary hippocampal neurons, we observed that a brief treatment with …