[HTML][HTML] Role of NF-κB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide
C Tiruppathi, J Shimizu, K Miyawaki-Shimizu… - Journal of biological …, 2008 - ASBMB
We investigated the role of NF-κB activation by the bacterial product lipopolysaccharide
(LPS) in inducing caveolin-1 (Cav-1) expression and its consequence in contributing to the
leakiness of the endothelial barrier. We observed that LPS challenge of human lung
microvascular endothelial cells induced concentration-and time-dependent increases in
expression of Cav-1 mRNA and protein. The NEMO (NF-κB essential modifier binding
domain)-binding domain peptide (IkB kinase (IKK)-NEMO-binding domain (NBD) peptide) …
(LPS) in inducing caveolin-1 (Cav-1) expression and its consequence in contributing to the
leakiness of the endothelial barrier. We observed that LPS challenge of human lung
microvascular endothelial cells induced concentration-and time-dependent increases in
expression of Cav-1 mRNA and protein. The NEMO (NF-κB essential modifier binding
domain)-binding domain peptide (IkB kinase (IKK)-NEMO-binding domain (NBD) peptide) …