[HTML][HTML] NADPH oxidase activation increases the sensitivity of intracellular Ca2+ stores to inositol 1, 4, 5-trisphosphate in human endothelial cells
Many stimuli that activate the vascular NADPH oxidase generate reactive oxygen species
and increase intracellular Ca 2+, but whether NADPH oxidase activation directly affects Ca
2+ signaling is unknown. NADPH stimulated the production of superoxide anion and H 2 O 2
in human aortic endothelial cells that was inhibited by the NADPH oxidase inhibitor
diphenyleneiodonium and was significantly attenuated in cells transiently expressing a
dominant negative allele of the small GTP-binding protein Rac1, which is required for …
and increase intracellular Ca 2+, but whether NADPH oxidase activation directly affects Ca
2+ signaling is unknown. NADPH stimulated the production of superoxide anion and H 2 O 2
in human aortic endothelial cells that was inhibited by the NADPH oxidase inhibitor
diphenyleneiodonium and was significantly attenuated in cells transiently expressing a
dominant negative allele of the small GTP-binding protein Rac1, which is required for …