The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen
ablative therapy and mediates growth of androgen-insensitive prostate cancer cells,
suggesting it is activated by nonandrogenic factors. We demonstrate that activated α subunit
of heterotrimeric guanine nucleotide-binding G s protein activates the AR in prostate cancer
cells and also synergizes with low concentration of androgen to more fully activate the AR.
The Gα s activates protein kinase A, which is required for the nuclear partition and activation …