Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis
P Gao, CCL Wong, EKK Tung, JMF Lee, CM Wong… - Journal of …, 2011 - Elsevier
BACKGROUND & AIMS: Deregulation of microRNAs (miRNAs) plays an important role in
human carcinogenesis. However, miRNA deregulation in the pre-malignant lesions and
expression changes during multistep hepatocarcinogenesis remain elusive. METHODS: In
this study, we investigated the expression changes of seven cancer-related miRNAs during
the early stages of HBV related hepatocarcinogenesis. The miRNA was extracted from
formalin fixed paraffin embedded (FFPE) dysplastic nodules (DN), small HCCs, and their …
human carcinogenesis. However, miRNA deregulation in the pre-malignant lesions and
expression changes during multistep hepatocarcinogenesis remain elusive. METHODS: In
this study, we investigated the expression changes of seven cancer-related miRNAs during
the early stages of HBV related hepatocarcinogenesis. The miRNA was extracted from
formalin fixed paraffin embedded (FFPE) dysplastic nodules (DN), small HCCs, and their …