[HTML][HTML] MicroRNA-148a is down-regulated in human pancreatic ductal adenocarcinomas and regulates cell survival by targeting CDC25B
ST Liffers, JB Munding, M Vogt, JD Kuhlmann… - Laboratory …, 2011 - Elsevier
MicroRNAs (miRNAs: short non-coding RNAs) are emerging as a class of potential novel
tumor markers, as their dysregulation is being increasingly reported in various types of
cancers. In the present study, we investigated the transcription status of miRNA-148a (miR-
148a) in human pancreatic ductal adenocarcinoma (PDAC) and its role in the regulation of
the dual specificity protein phosphatase CDC25B. We observed that miR-148a exhibited a
significant 4-fold down-regulation in PDAC as opposed to normal pancreatic ductal cells. In …
tumor markers, as their dysregulation is being increasingly reported in various types of
cancers. In the present study, we investigated the transcription status of miRNA-148a (miR-
148a) in human pancreatic ductal adenocarcinoma (PDAC) and its role in the regulation of
the dual specificity protein phosphatase CDC25B. We observed that miR-148a exhibited a
significant 4-fold down-regulation in PDAC as opposed to normal pancreatic ductal cells. In …