Ghrelin and glucose homeostasis

PJD Delhanty, AJ van der Lely - Peptides, 2011 - Elsevier
Ghrelin plays an important physiological role in modulating GH secretion, insulin secretion
and glucose metabolism. Ghrelin has direct effects on pancreatic islet function. Also, ghrelin
is part of a mechanism that integrates the physiological response to fasting. However,
pharmacologic studies indicate the important obesogenic/diabetogenic properties of ghrelin.
This is very likely of physiological relevance, deriving from a requirement to protect against
seasonal periods of food scarcity by building energy reserves, predominantly in the form of …