[HTML][HTML] Context-specific effects of Fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion: Fibulin-5 is induced by transforming growth factor-β and affects …
WP Schiemann, GC Blobe, DE Kalume… - Journal of Biological …, 2002 - ASBMB
Fibulin-5 (FBLN-5; also known as DANCE or EVEC) is an integrin-binding extracellular
matrix protein that mediates endothelial cell adhesion; it is also a calcium-dependent elastin-
binding protein that scaffolds cells to elastic fibers, thereby preventing elastinopathy in the
skin, lung, and vasculature. Transforming growth factor-β (TGF-β) regulates the production of
cytokines, growth factors, and extracellular matrix proteins by a variety of cell types and
tissues. We show here that TGF-β stimulates murine 3T3-L1 fibroblasts to synthesize FBLN …
matrix protein that mediates endothelial cell adhesion; it is also a calcium-dependent elastin-
binding protein that scaffolds cells to elastic fibers, thereby preventing elastinopathy in the
skin, lung, and vasculature. Transforming growth factor-β (TGF-β) regulates the production of
cytokines, growth factors, and extracellular matrix proteins by a variety of cell types and
tissues. We show here that TGF-β stimulates murine 3T3-L1 fibroblasts to synthesize FBLN …