[HTML][HTML] X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-β-mediated nuclear factor-κB activation during breast …
JR Neil, M Tian, WP Schiemann - Journal of biological chemistry, 2009 - ASBMB
The precise sequence of events that enable mammary tumorigenesis to convert
transforming growth factor-Β (TGF-Β) from a tumor suppressor to a tumor promoter remains
incompletely understood. We show here that X-linked inhibitor of apoptosis protein (xIAP) is
essential for the ability of TGF-Β to stimulate nuclear factor-κB (NF-κB) in metastatic 4T1
breast cancer cells. Indeed whereas TGF-Β suppressed NF-κB activity in normal mammary
epithelial cells, those engineered to overexpress xIAP demonstrated activation of NF-κB …
transforming growth factor-Β (TGF-Β) from a tumor suppressor to a tumor promoter remains
incompletely understood. We show here that X-linked inhibitor of apoptosis protein (xIAP) is
essential for the ability of TGF-Β to stimulate nuclear factor-κB (NF-κB) in metastatic 4T1
breast cancer cells. Indeed whereas TGF-Β suppressed NF-κB activity in normal mammary
epithelial cells, those engineered to overexpress xIAP demonstrated activation of NF-κB …