[PDF][PDF] Comparative effects of L-methionine, S-adenosyl-L-methionine and 5'-methylthioadenosine on the growth of preneoplastic lesions and DNA methylation in rat …
RM Pascale, MM Simile, G Satta, MA Seddaiu… - Anticancer …, 1991 - researchgate.net
Male Wistar rats, initiated with diethylnitrosamine (DENA), were subjected to a selection
treatment, according to the “resistant hepatocyte” model, followed or not followed by
phenobabarbital (PB). Rats received, for 3 weeks after selection, 4 im doses (96 mmol/kg) of
L-methionine, S-adenosyl-L-methionine (SAM), or 5'-methylthioadenosine (MTA), a SAM
catabolite formed during polyamine synthesis or by spontaneous splitting of SAM at
physiologic temperature and pH. They were then killed. In some rats, SAM and MTA …
treatment, according to the “resistant hepatocyte” model, followed or not followed by
phenobabarbital (PB). Rats received, for 3 weeks after selection, 4 im doses (96 mmol/kg) of
L-methionine, S-adenosyl-L-methionine (SAM), or 5'-methylthioadenosine (MTA), a SAM
catabolite formed during polyamine synthesis or by spontaneous splitting of SAM at
physiologic temperature and pH. They were then killed. In some rats, SAM and MTA …