[HTML][HTML] Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver
ML Batten, Y Imanishi, T Maeda, DC Tu… - Journal of Biological …, 2004 - ASBMB
Lecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented
epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal
pigmented epithelium, LRAT plays a key role in the retinoid cycle, a two-cell recycling
system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. We
disrupted mouse Lrat gene expression by targeted recombination and generated a
homozygous Lrat knock-out (Lrat-/-) mouse. Despite the expression of LRAT in multiple …
epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal
pigmented epithelium, LRAT plays a key role in the retinoid cycle, a two-cell recycling
system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. We
disrupted mouse Lrat gene expression by targeted recombination and generated a
homozygous Lrat knock-out (Lrat-/-) mouse. Despite the expression of LRAT in multiple …