[HTML][HTML] Wnt/β-catenin signaling is a normal physiological response to mechanical loading in bone
JA Robinson, M Chatterjee-Kishore… - Journal of Biological …, 2006 - ASBMB
A preliminary expression profiling analysis of osteoblasts derived from tibia explants of the
high bone mass LRP5 G171V transgenic mice demonstrated increased expression of
canonical Wnt pathway and Wnt/β-catenin target genes compared with non-transgenic
explant derived osteoblasts. Therefore, expression of Wnt/β-catenin target genes were
monitored after in vivo loading of the tibia of LRP5 G171V transgenic mice compared with
non-transgenic mice. Loading resulted in the increased expression of Wnt pathway and …
high bone mass LRP5 G171V transgenic mice demonstrated increased expression of
canonical Wnt pathway and Wnt/β-catenin target genes compared with non-transgenic
explant derived osteoblasts. Therefore, expression of Wnt/β-catenin target genes were
monitored after in vivo loading of the tibia of LRP5 G171V transgenic mice compared with
non-transgenic mice. Loading resulted in the increased expression of Wnt pathway and …