Pools of overlapping peptides corresponding to specific antigens are frequently used to
identify T cell immune responses to vaccines or pathogens. While the response to the entire
pool of peptides provides important information, it is often desirable to also know to which
individual peptides within the pool the immune responses are directed. In this report, we
analyzed various ways of deconvoluting an immune response to a pool of peptides to
determine the number of different peptides to which the T cells are responding. We used a …